Outline of Labolatory
Cell Functional Molecular Chemistry
Mizukami lab.
Mizukami lab.
In living organisms and cells, various biomolecules such as proteins, nucleic acids, and carbohydrates function through intricate interactions with each other. To truly understand the roles of these biomolecules, it is essential to observe their behaviors and functions under physiological conditions—namely, within living systems where their interactions with other biomolecules are preserved. Our research particularly focuses on developing new technologies that enable visualization and functional control of biomolecules using light. Specifically, we are working on the development of fluorescent probes for quantitative imaging of metal ions in subcellular regions, as well as photoresponsive compounds that can induce protein-protein interactions upon light irradiation to control intracellular signal transduction. By combining these functional molecules with fluorescence microscopy, we aim to uncover the physiological roles of molecules and ions, as well as the underlying mechanisms of diseases, within cells.
