Kenji Inaba
Professor
Hiroshi Kadokura
Associate Professor
Yuta Amagai
Assistant Professor
Satoshi Watanabe
Assistant Professor
Keywords
  • X-ray crystal structure analysis
  • cellular homeostasis
  • protein quality control
  • redox
  • calcium ion

Major Grad.Sch. of Science; Grad.Sch. of Life Sciences
Web Site http://www2.tagen.tohoku.ac.jp/lab/inaba/html/

Toward elucidation of cellular mechanisms underlying protein and metal ion homeostasis

The biological kingdoms have evolved elaborate systems to maintain the cellular homeostasis. Employing structural, biochemical, proteomic and cell biological approaches, we aim at deep understanding of mechanisms by which protein quality and metal ion concentration are controlled in living cells. In particular, we focus on the protein disulfide bond formation network and calcium ion transporters present in the endoplasmic reticulum. Structural and mechanistic insights gained in this work will provide molecular views about how neurodegenerative diseases are caused by impairment of these cellular quality control systems.

Themes

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