We study advanced nano-micro technologies in chemistry and biochemistry and their applications to integrated analytical devices. We investigate easy and automated analytical technologies for life science, environmental science, food safety, and industrial process. We also investigate novel analytical technologies such as single cell analysis, single molecule analysis, single event analysis, and molecular behavior in rapid mixing. For the advanced technologies, fundamental chemistry such as chemical reaction and phase transition in a confined space should be revealed in detail. We study unique advanced measurement tools such as microscopic imaging, laser microscopy, and electron spin resonance(ESR)spectroscopy.