Takehiko Wada

Professor

Yasuyuki Araki

Associate Professor

Hirofumi Kurokawa

Senior Assistant Professor

Masaki Nishijima

Assistant Professor

Satoko Suzuki

Assistant Professor

Design and Synthesis of Artificial Nucleic Acid and Protein for Active Control of Cellular Function and Development of High Sensitive & Time Resolve CD System

Chemical synthesis and modification of DNA/RNA and proteins are the fundamental science and technology that have led the molecular biology revolution. Hence, a chemistry of DNA/RNA and protein not only in vitro but also in vivo expects to open new generational stage of bioorganic chemistry and molecular biology. Therefore, focusing our research interest is mostly on the recognition and complexation behavior control of functional biopolymers, such as DNA/RNA, proteins, and their derivatives by external factors, toward the active control of cellular functions. Another research topics of Wada Lab. are reaction control based on molecular recognition phenomena in both the ground and electronically excited states; we are pursuing mechanistic and synthetic studies on asymmetric photo chirogenesis with supramolecular biopolymers as chiral reaction medias.

Themes

• Development of external stimuli responsible artificialnucleic acids
• Creation of intra-cellular environment changeresponsible functional molecules
• Creation of cancer cell specific oligonucleotide therapeutic molecules
• Supramolecular Asymmetric Photochirogenesiswith biopolymers and bio-molecules as a nano-chiralreaction media
• Development of High Sensitive and High Time-Resolve Circular Dichroism (CD) Detection Method for Analysis of Supramolecular Dynamic