Professor

Takehiko Wada

Associate Professor

Yasuyuki Araki

Assistant Professor

Mitsuyo Matsumoto

Assistant Professor

Satoko Suzuki

Design and Synthesis of Artificial Nucleic Acid and Protein for Active Control of Cellular Function and Development of High Sensitive & Time Resolve CD System

Chemical synthesis and modification of DNA/RNA and proteins are the fundamental science and technology that have led the molecular biology revolution. Hence, the chemistry of DNA/RNA and protein not only in vitro but also in vivo expects to open the new generational stages of bioorganic chemistry and molecular biology. Therefore, focusing our research interest is mostly on the recognition and complexation behavior control of functional biopolymers, such as DNA/ RNA, proteins, and their derivatives by external factors, toward the active control of cellular functions. Another research topics of Wada Lab. are reaction control based on molecular recognition phenomena in both the ground and electronically excited states. Our laboratory is also working on the development of high-sensitive and high timeresolved circular dichroism (CD) spectrum measurement system, creation of circularly polarized luminescence (CPL) material/device, which is attracting attention as the next 3D display material, and supramolecular asymmetric photochirogenesis utilizing proteins as a chiral reaction media.

Themes

• Development of external stimuli responsible artificial nucleic acids
• Creation of intra-cellular environment change responsible functional molecules
• Creation of cancer cell specific oligonucleotide therapeutic molecules
• Supramolecular Asymmetric Photochirogenesis with biopolymers and bio-molecules as a nano-chiral reaction media
• Development of High Sensitive and High Time-Resolve Circular Dichroism (CD) Detection Method for Analysis of Supramolecular Dynamic